栄研スタッフによる解説論文集 資料　作成日　98/01/21
	Inhibitory action of some flavonoids on enhanced spontaneous lipid peroxidation following gIutathione depletion
	著者: Younes, M., Siegers, C.-P.
	出典: Planta Medica, 43, 240-244(1981)

要約

Depletion of hepatic glutathione in phenobarbital-induced rats by phorone (diisopropylidene acetone) led to an enhancement of spontaneous lipid peroxidation in vitro. Addition of exogenous glutathione, dithiocarb or one of the flavonoids (+)-catechin, (-)-epicatechin, 3-O-methylcatechin, quercetin, taxifolin, rutin, naringin or naringenin led in every case to a dose-dependent inhibition of this peroxidative activity. The concentration values yielding 50 % inhibition (I50) varied from 1.0 × 10-6 M for glutathione to 1.9 × 10-5 M for naringenin. Naringin and naringenin, which lack the 3'-OH-group, were the least active inhibitors. The only structural feature of the flavonoids which affects their antioxidative action appears thus to be the 3',4'-dihydroxy-grouping.

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