栄研スタッフによる解説論文集 資料　作成日　98/02/03
	Effects of flavonoids on cytochrome P-450 from rat liver microsomes : inhibition of enzyme activities and protection against peroxidative damage
	著者: Ubeda, A., Esteve, M. L., Alcaraz, M. J., Cheesemen, K. H. and Slater, T. F.
	出典: Phytother. Res, 9, 416-420 (1995)

要約

A series of flavonoids, able to inhibit non-enzymic and enzymic lipid peroxidation, were investigated as inhibitors of cytochrome P-450 mediated reactions (aminopyrine N-demethylation and aniline hydroxylation) in rat liver microsomes. The most potent compounds were chrysin, luteolin, amentoflavone and eriodictyol (amminopyrine N-demethylation) and apigenin, kaempferol and quercetin (aniline hydroxylation). Some structure-activity relationships were established for inhibition of aminopyrine N-demethylation and it was observed that the resorcinol configuration of the ring A is a determinant feature, whereas O-glycosylation abolished the activity. Most of the compounds showed lower activity on aniline hydroxylation. The presence of these flavonoids during incubation of microsomes in a medium containing NADPH did not modify the cytochrome P-450 concentration and protected against lipid peroxidation induced degradation of this cytochrome.

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