栄研スタッフによる解説論文集 資料　作成日　98/01/21
	Inhibition of lipooxygenase-dependent lipid peroxidation by quercetin: Mechanism of antioxdative function
	著者: Takahama, U.
	出典: Phytochemistry, 24, 1443-1446(1985)

要約

Quercetin inhibited soybean lipoxygenase-1-dependent linoleic acid peroxidation. Two to three μM quercetin was required for 50% inhibition. During the inhibition, quercetin was oxidized. The oxidation was observed as an absorbance decrease at about 380 nm and an absorbance increase at about 335 nm. Inhibition of linoleic acid peroxidation by qucrcetin seems to be due to reduction by the reagent of the linoleic acid radical formed as an intermediate during lipoxygenation. Quercetin oxidation was suppressed by ascorbate under conditions when ascorbate did not affect lipoxygenase-dependent linoleic acid peroxidation. The results suggest that aseorbate can reduce the quercetin oxidized by the linoleic acid radical back to quercetin. Based on the results, the significance of a redox reaction between oxidized quercetin and ascorbate is discussed.

(c) All Copyrights reserved 2001 National Institute of Health and Nutrition