栄研スタッフによる解説論文集 資料　作成日　98/01/21
	Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation
	著者: Mora, A., Paya, M., Rios, J. L. and Alcaraz, M. J.
	出典: Biochem Pharmacol, 40, 793-797(1990)

要約

Polymethoxylated flavones and C-glycosyl derivatives isolated from medicinal plants besides other flavonoid compounds were studied for their influence on lipid peroxidation induced by FeS04+cysteine in rat liver microsomes. A number of hydroxyflavones (e.g. luteolin); C-glycosylflavones (e,g. orientin); methoxyflavones (e.g. gardenin D) and flavonols (e.g. datiscetin), as well as the fiavanol leucocyanidol and the biflavone amentoflavone behaved as inhibitors of non-enzymic lipid peroxidation. Structure-activity relationships were established and it was observed that the structural features for active polyhydroxylated compounds were different from those of polymethoxylated flavones, antiperoxidative flavonoids possessing a high lipophilicity.

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