栄研スタッフによる解説論文集 資料　作成日　98/02/03
	In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin
	著者: Hope, W. C., Welton, A. F., Nagy, F. C., Bernard, C. B., Coffey, J. W.
	出典: Biochem Pharmacol, 32, 367-371(1983)

要約

In summary, quercetin has been shown to be a potent inhibitor of histamine release and SRS-A biosynthesis in vitro. Since quercetin was also shown to be a potent inhibitor of Δ5-lipoxygenase activity from RBL-1 cells and Δ12-lipoxygenase activity from human platelets, one of the mechanisms by which this drug inhibits SRS-A biosynthesis may involve the inhibition of a Δ5-lipoxygenase. These studies suggest that quercetin may be an interesting prototype for a drug which is both an inhibitor of general mediator release (like DSCG) and an inhibitor of SRS-A biosynthesis (like NDGA).

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