栄研スタッフによる解説論文集 資料　作成日　98/01/20
	Disposition of quercetin in man after single oral and intravenous doses
	著者: Gugler, R., Leschik, M. and Dengler, H. J.
	出典: Europ. J. clin. Phamacol, 9, 229-234(1975)

要約

The pharmacokinetics of quercetin, a flavonoid, have been studied in 6 volunteers after single intravenous (100 mg) and oral (4 g) doses. The data after iv administration were analyzed according to a two compartment open model with half lives of 8.8 ± 1.2 min for the　αphase and 2.4 ± 0.2 h for the βPhase (predominant half life) , respectively. Protein binding was >98%. The apparent volume of distribution was small at 0.34 ± 0.03 l/kg. Of the intravenous dose 7.4± 1.2% was excreted in urine as a conjugated metabolite, and 0.65 ± 0.1% was excreted unchanged. After oral administration no measurable plasma concentrations could be detected, nor was any quercetin found in urine, either unchanged or in a metabolized form. These results exclude absorption of more than 1% of unchanged drug. Recovery in faeces after the oral dose was 53 ± 5%, which suggests extensive degradation by microorganisms in the gut. The data obtained show that oral administration of flavonoids may be of questionable value.

(c) All Copyrights reserved 2001 National Institute of Health and Nutrition