栄研スタッフによる解説論文集 資料　作成日　98/02/03
	Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation
	著者: Cholbi, M. R., Paya, M. and Alcaraz, M. J.
	出典: Experientia, 47, 195-199(1991)

要約

The antiperoxidative effects of 35 phenolic compounds, most of them belonging to the flavonoid class, were investigated using CCl4-induced peroxidation of rat liver microsomes. This system was rather insensitive to gallic acid, methyl gallate and ellagic acid. Nevertheless it was inhibited by flavonoids and structure/activity relationships were established. The most potent compounds were gardenin D, luteolin, apigenin (flavones), datiscetin, morin, galangin (flavonols), eriodictyol (flavanone), amentoflavone (biflavone) and the reference compound, (+)-catechin. The natural polymethoxyflavone gardenin D has shown a potency comparable to that of (+)-catechin and higher than that of silybin. Thus, it may be considered as a new type of natural antioxidant with potential therapeutical a applications.

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